Nicaragua revisited: evidence of lower prevalence of chronic kidney disease in a high-altitude, coffee-growing village

作者：Laux Timothy S^*; Bert Philip J; Barreto Ruiz Gerardo M; Gonzalez Marvin; Unruh Mark; Aragon Aurora; Torres Lacourt Cecilia

来源：Journal of Nephrology, 2012, 25(4): 533-540.

DOI：10.5301/jn.5000028

• Altitude
• Chronic kidney disease
• Nicaragua
• Pesticides
• Risk factors
• Rural

Background: Chronic kidney disease (CKD) is found at epidemic levels in certain populations of the Pacific Coast in northwestern Nicaragua especially in younger men. There are knowledge gaps concerning CKD%26apos;s prevalence in regions at higher altitudes. %26lt;br%26gt;Methods: A cross-sectional study of adults between the ages of 20 and 60 years in 1 coffee-growing village in Nicaragua located at 1,000 m above sea level (MASL) altitude was performed. Predictors included participant sex, age, occupation, conventional CKD risk factors and other factors associated with CKD suggested by previous surveys in Central America. Outcomes included serum creatinine (SCr) values %26gt;1.2 mg/dL for men and %26gt;0.9 mg/dL for women, estimated glomerular filtration rate (GFR) %26lt;60 ml/min per 1.73 m(2), dipstick proteinuria stratified as microalbuminuria (30-300 mg/dL) and macroalbuminuria (%26gt;300 mg/dL), hypertension and body mass index. %26lt;br%26gt;Results: Of 324 eligible participants, 293 were interviewed (90.4%), and 267 of those received the physical exam (82.4% overall). Of the sample, 45% were men. Prevalence rate of estimated GFFI %26lt;60 ml/min per 1.73 m(2) was 0 men (0%) and 2 for women (1.4%). The prevalence of at least microalbuminuria was significantly higher among men compared with women (27.5% vs. 21.4%, respectively; p=0.02). %26lt;br%26gt;Conclusions: The CKD prevalence in this village is comparable to a previously studied Nicaraguan coffee-farming region and much lower than previously screened portions of northwestern Nicaragua. There is heterogeneity in CKD prevalence across Nicaragua. At this time, screenings should target individuals living in previously identified, higher risk regions. More work is needed to understand determinants of CKD in this resource-poor nation.

• 出版日期2012-8