A Stereoselective Three-Component Reaction: The Facile Synthesis of Fluorinated Tetrahydropyrimido[1,2-b]benzothiazoles

作者：Shaabani A^*; Rahmati A; Rezayan A H; Khavasi H R

来源：Journal of the Iranian Chemical Society, 2011, 8(1): 24-30.

DOI：10.1007/bf03246198

• Fluorinated compound
• 2-Aminobenzothizole
• 3-Amino-1,2,4-triazole
• Solvent-free
• Catalyst-free

A one-pot, catalyst- and solvent-free approach has been developed for the stereoselective synthesis of fluorinated tetrahydropyrimido[1,2-b]benzothiazoles. The three-component condensation reaction of an aldehyde and a trifluoromethyl beta-dicarbonyl compound in the presence of 2-aminobenzothizole occurs in high yields at 90 degrees C.

• 出版日期2011-3