A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid

作者：Zhang Yong; Khan M Naseer A; Gong Ping; Lee Yong Sup^*

来源：Chinese Chemical Letters, 2009, 20(8): 898-900.

DOI：10.1016/j.cclet.2009.03.032

• 2-Hydroxy-4-oxo-4-phenylbutanoates
• Malic acid
• Friedel-Crafts reaction

A synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently, which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors.

• 出版日期2009-8
• 单位沈阳药科大学