Association Between Individual PM2.5 Exposure and DNA Damage in Traffic Policemen

作者：Li, Pengkun; Zhao, Jinzhuo; Gong, Changyi; Bo, Liang; Xie, Yuquan^*; Kan, Haidong; Song, Weimin

来源：Journal of Occupational and Environmental Medicine, 2014, 56(10): E98-E101.

DOI：10.1097/JOM.0000000000000287

• POLYCYCLIC AROMATIC-HYDROCARBONS
• WHITE BLOOD-CELLS
• AIR-POLLUTION
• PARTICULATE MATTER
• HYPERTENSIVE-RATS
• FINE PARTICLES
• ADDUCT LEVELS
• BIOMARKERS
• 1-HYDROXYPYRENE
• INFLAMMATION

Objective: The aim of this study was to explore the association between individual PM2.5 and DNA damage in traffic policemen. Methods: The participants included 110 traffic policemen and 101 common populations. The continuous 24-hour individual PM2.5 measurement was performed in participants. BPDE (benzo[a]pyrene 7,8-diol-9,10-epoxide)-DNA adducts and 1-OHP were detected. Results: The average concentration of 24-hour personal PM2.5 for traffic policemen was significantly higher than that in the control group. PM2.5 exposure is associated with a 1.1% increase in 1-OHP and 0.8% increase in BPDE-DNA adducts after adjusted for body mass index, educational time period, and alcohol intake. Exposure group has 2.04 times higher of 1-OHP and 1.25 times higher of BPDE-DNA adducts when compared to the control group. Conclusions: These results demonstrated that traffic policemen have been a high-risk group suffering DNA damage because of the high PM2.5 exposure.

• 出版日期2014-10
• 单位复旦大学; 上海交通大学