Membrane associated matrix metalloproteinases in metastasis

作者：Ellerbroek SM; Stack MS^*

来源：BioEssays, 1999, 21(11): 940-949.

DOI：10.1002/(SICI)1521-1878(199911)21:11<940::AID-BIES6>3.0.CO;2-J

Hematogenous metastasis is postulated to involve tumor cell-initiated degradation of basement membrane barriers and underlying connective tissue matrices. Matrix metalloproteinases (MMP) are zinc-dependent endopeptidases that have been implicated in the proteolytic events of tumor cell invasion. Research has revealed a class of membrane-anchored metalloproteinases (MT-MMPs) and has provided convincing evidence that these enzymes activate latent MMP-2 (72 kDa gelatinase A) on the cell surface, The activation of plasma membrane associated MMP is a potential mechanism for facilitation of cellular metastasis and requires consideration when addressing potential roles of MMPs in tumor progression. This review focuses on potential in vivo regulatory mechanisms of membrane-associated MMP activity in the context of tumor cell interaction with matrix macromolecules. BioEssays 1999;21:940-949.

• 出版日期1999-11
• 单位西北大学