A label-free electrochemical immunosensor based on AgPt nanorings supported on reduced graphene oxide for ultrasensitive analysis of tumor marker

作者：Wang, Rui; Feng, Jiu-Ju^*; Xue, Yadong; Wu, Liang; Wang, Ai-Jun^*

来源：Sensors and Actuators B: Chemical , 2018, 254: 1174-1181.

DOI：10.1016/j.snb.2017.08.009

• Label-free immunosensor
• AgPt nanorings
• Reduced graphene oxide
• Carcinoembryonic antigen

Herein, a new label-free electrochemical immunosensor was constructed for carcinoembryonic antigen (CEA) detection based on AgPt nanorings supported on reduced graphene oxide (AgPt NRs-rGO) synthesized by a one-pot wet-chemical route with the assistance of 2,4-dihydroxypyridine (DHP) as a new growth-directing agent. The nanocomposites were mainly characterized by transmission electron microscopy (TEM), high-resolution TEM (HRTEM), high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). By virtue of the incorporated Ag as the redox mediator, the AgPt NRs-rGO-based immunosensor showed the wide linear range of 5 fg mL(-1)-50 ng mL(-1) for the detection of CEA, with a low detection limit of 1.43 fg mL(-1), which providing a promising platform for clinical research and diagnosis.

• 出版日期2018-1
• 单位浙江师范大学