A pair of epimeric cassane-type diterpenoids and a new labdane-type derivative from Caesalpinia decapetala

作者：Qiao, Yuben; Liu, Yanfei; Duan, Xueyan; Chen, Chunmei; Liu, Junjun; Zhu, Hucheng; Xue, Yongbo^*; Zhang, Yonghui^*

来源：Tetrahedron, 2018, 74(28): 3852-3857.

DOI：10.1016/j.tet.2018.05.028

• Caesalpinia decapetala (Roth) Alston
• Cassane-type furanoditerpenoid
• Mixture of epimers
• ECD calculations
• Antibacterial activities

Caesaldecins A and B (1a/1b), a pair of epimeric cassane-type diterpenoids containing an ether linkage between C-6 and C-20 and an alpha,beta-butenolide ring in the northern hemisphere, were isolated from the leaves of the medicinal plant Caesalpinia decapetala (Roth) Alston, along with a new labdane-type diterpenoid, termed as 8(17),11(Z),13(E)-trien-15,18-dioic acid (2). Structures of 1 and 2 were established by extensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR, and electronic circular dichroism (ECD) calculations. The in vitro antibacterial and inhibitory activities against a panel of bacteria and cancer cell lines were evaluated, respectively. Compound 2 displayed moderate antibacterial activity against the methicillin-resistant Staphylococcus aureus subsp. aureus (MRSA) with an MIC50 value of 5.99 mu gmL(-1).

• 出版日期2018-7-12
• 单位华中科技大学; 武汉市中心医院