Anti-IFN-alpha/beta Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice

作者：Baccala Roberto^*; Gonzalez Quintial Rosana; Schreiber Robert D; Lawson Brian R; Kono Dwight H; Theofilopoulos Argyrios N

来源：The Journal of Immunology, 2012, 189(12): 5976-5984.

DOI：10.4049/jimmunol.1201477

The demonstration in humans and mice that nucleic acid-sensing TLRs and type I IFNs are essential disease mediators is a milestone in delineating the mechanisms of lupus pathogenesis. In this study, we show that Ifnb gene deletion does not modify disease progression in NZB mice, thereby strongly implicating IFN-alpha subtypes as the principal pathogenic effectors. We further document that long-term treatment of male BXSB mice with an anti-IFN-alpha/beta receptor Ab of mouse origin reduced serologic, cellular, and histologic disease manifestations and extended survival, suggesting that disease acceleration by the Tlr7 gene duplication in this model is mediated by type I IFN signaling. The efficacy of this treatment in BXSB mice was clearly evident when applied early in the disease process, but only partial reductions in some disease characteristics were observed when treatment was initiated at later stages. A transient therapeutic effect was also noted in the MRL-Fas(lpr) model, although overall mortality was unaffected. The combined findings suggest that IFN-alpha/beta receptor blockade, particularly when started at early disease stages, may be a useful treatment approach for human systemic lupus erythematosus and other autoimmune syndromes. The Journal of Immunology, 2012, 189: 5976-5984.

• 出版日期2012-12-15