科研之友
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摘要
Purpose: This study was conducted to explore the diagnostic value of microRNA-143 (miRNA-143) in predicting instent restenosis (ISR) of lower extremity arterial occlusive disease (LEAOD). @@@ Methods: From February 2012 to March 2015, 165 patients (112 males and 53 females) with LEAOD undergoing interventional treatment were enrolled in this study. Serum miRNA-143 expression was detected using quantitative real-time polymerase chain reaction (qRT-PCR). Patients were assigned into the restenosis and non-restenosis groups according to routine surveillance postoperative angiography. A logistic regression analysis was conducted to analyze the risk factors for ISR in LEAOD patients. A receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic value of miRNA-143 in predicting ISR for LEAOD patients. @@@ Results: There were 74 and 91 patients in the restenosis and non- restenosis groups, respectively. Before the treatment, there were significant differences in history of diabetes, smoking status, blood sugar level (BSL) at admission, low-density lipoprotein cholesterol (LDL-C) level, and stent diameter between the restenosis and non- restenosis groups (all P < 0.05). Serum miRNA-143 expression was lower in the restenosis group than in the non- restenosis group (P < 0.05). Serum miRNA-143 expression in the restenosis group was correlated with smoking status, history of diabetes, BSL, and LDL-C (all P < 0.05). Logistic regression analysis demonstrated that miRNA-143, LDL-C, and smoking status were correlated with the postoperative ISR (all P < 0.05). ROC curve analysis revealed that the area under the curve (AUC) of miRNA-143 in predicting ISR for LEAOD patients was 0.866. @@@ Conclusion: Our results indicate that miRNA-143 can be a promising tool for predicting the ISR in LEAOD patients.
- 出版日期2017-1-5
- 单位宁波大学
