Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population

作者：Wang, Yanyun; Zhou, Bin; Zhao, Yi; Yu, Xiuzhang; Liu, Yi^*; Zhang, Lin^*

来源：Disease Markers, 2016, 2016: 2460206.

DOI：10.1155/2016/2460206

• INTERLEUKIN-32 EXPRESSION
• CYTOKINES
• COLLEGE
• CANCER
• REGION
• ALPHA

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. IL-32, a secreted protein, has been reported to be associated with several autoimmune diseases. Our preliminary experiment showed different plasma IL-32 levels than that mentioned in a published report on the same population. In order to elucidate the correlation between IL-32 and SLE, we determined the plasma level and two single nucleotide polymorphisms (SNPs) of IL-32 in 152 patients with SLE and 310 healthy controls and analyzed the relationship based on the clinical parameters. The results showed that plasma IL-32 levels in patients with SLE were markedly lower than that in the healthy controls. In the SLE group, patients with detectable IL-32 presented low serum C3 concentrations. Further studies indicated that the rs28372698 SNP was associated with the susceptibility to SLE. Taken together, our results suggested that IL-32 could possibly be a candidate marker to monitor SLE disease stability and screening in future.

• 出版日期2016
• 单位四川大学