Acetyl- and O-alkyl- derivatives of beta-mangostin from Garcinia mangostana and their anti-inflammatory activities

作者：Karunakaran Thiruventhan; Ee Gwendoline Cheng Lian^*; Ismail Intan Safinar; Nor Siti Mariam Mohd; Zamakshshari Nor Hisam

来源：Natural Product Research, 2018, 32(12): 1390-1394.

DOI：10.1080/14786419.2017.1350666

• Acetyl- and O-alkyl-beta-mangostin
• anti-inflammation
• beta-mangostin

Pure -mangostin (1) was isolated from the stem bark of Garcinia mangostana L. One monoacetate (2) and five O-alkylated -mangostin derivatives (3-7) were synthesised from -mangostin. The structures of these compounds were elucidated and determined using spectroscopic techniques such as 1D NMR and MS. The cytotoxicities and anti-inflammatory activities of these five compounds against RAW cell 264.7 were tested. The structural-activity relationship studies indicated that -mangostin showed a significant activity against the LPS-induced RAW cell 264.7, while the acetyl- as well as the O-alkyl- -mangostin derivatives did not give good activity. Naturally occurring -mangostin demonstrated comparatively better anti-inflammatory activity than its synthetic counterparts.
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• 出版日期2018