A New Isoflavonoid from Seeds of Lepidium sativum L. and Its Protective Effect on Hepatotoxicity Induced by Paracetamol in Male Rats

作者：Sakran Mohamed; Selim Yasser^*; Zidan Nahla

来源：Molecules, 2014, 19(10): 15440-15451.

DOI：10.3390/molecules191015440

• Lepidium sativum
• isoflavonoid
• hepatotoxicity

A new isoflavonoid, 5,6-dimethoxy-2',3'-methylenedioxy-7-C-beta-D-gluco-pyranosyl isoflavone was isolated from the seeds of Lepidium sativum L. along with two known isoflavonoids, 7-hydroxy-4',5,6-trimethoxyisoflavone and 7-hydroxy-5,6-dimethoxy-2',3'-methylenedioxyisoflavone. The structures of all compounds were elucidated with NMR spectrometry. Compounds 1, 2 and the new isoflavonoid 3 were evaluated for their ability to reduce the hepatotoxicity induced by paracetamol in male rats by reducing the damage and toxicity effects on liver cells with a significant improvement of total antioxidant capacity, normalizing the levels of liver enzymes GSH, SOD, GPX, CAT and GST compared to control group.

• 出版日期2014-10