Association of E23K polymorphism of Kir6.2 gene with coronary artery disease

作者：Benlier Necla^*; Erdogan Mustafa; Ozkur Mehtap; Yildiz Oguzhan; Nacak Muradiye; Yamak Birol; Aynacioglu A Sukru

来源：African Journal of Pharmacy and Pharmacology, 2011, 5(4): 554-558.

• E23K polymorphism
• Kir6.2 gene
• coronary artery disease

The ATP-sensitive potassium (K(ATP)) channels are generally cardioprotective under conditions of metabolic impairment, consisting of pore-forming Kir 6.X (Kir 6.1 and Kir 6.2) subunits in combination with regulatory sulfonylurea receptor (SUR1, SUR2A and SUR2B) subunits. E23K is a missense single nucleotide polymorphism (SNP) located in the cytosolic proximal N-terminal tail of the Kir6.2 subunit. We investigated the E23K polymorphism of Kir6.2 gene in coronary artery disease (CAD) patients to assess its role in susceptibility to CAD. The CAD group included 340 patients (257 male and 83 female; mean age, 60.5 +/- 9.1 years) who underwent coronary angiography after recent myocardial infarction or angina. The control group consisted of 91 non cardiac individuals (45 male and 46 female; mean age, 55.6 +/- 9.4 years) with normal coronary vessels. The E23K polymorphism of Kir6.2 gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in CAD and control groups. The frequency of the G allele was found to be significantly higher in patients than in control group (58.2% vs. 47.8, p = 0.01). There were also significant differences in GG and combined (GA+AA) genotypes frequencies (35.9 vs. 23.1% and 64.1 vs. 76.9%, p = 0.02). The E23K polymorphism of Kir6.2 gene may be associated with the development of CAD.

• 出版日期2011-4
• 单位中国人民解放军军事医学科学院