Ultrahigh b-Values MRI in Normal Human Prostate: Initial Research on Reproducibility and Age-Related Differences

作者：Shi, Changzheng; Zhang, Dong; Xiao, Zeyu; Wang, Li; Ma, Rong; Chen, Hanwei^*; Luo, Liangping^*

来源：Journal of Magnetic Resonance Imaging, 2017, 46(3): 801-812.

DOI：10.1002/jmri.25629

• INTRAVOXEL INCOHERENT MOTION
• APPARENT DIFFUSION-COEFFICIENTS
• CANCER
• HYPERPLASIA
• PERFUSION
• TISSUE
• PARAMETERS
• LIVER

Purpose: To investigate the reproducibility of diffusion-weighted imaging (DWI) with ultrahigh b-values, and analyze the age-related differences in normal prostates. @@@ Materials and Methods: In all, 67 healthy participants were divided into three age groups (group A, 15- 30 years; group B, 31-50 years; group C, >= 51 years), and underwent DWI scanning twice with 15 b-factors from 0 to 3000 at 3.0T. Triexponential fits were applied to calculate the molecular diffusion coefficient (D), the pseudo-diffusion coefficient (D*), the ultrahigh apparent diffusion coefficient (ADC(uh)), and perfusion fraction (f). The interobserver and short-term interscan reproducibility were evaluated, and the change in these parameters with age were assessed. @@@ Results: The D, ADCuh, and f values presented good to excellent reproducibility. With increasing age, a trend of increasing D values was observed, with significant difference in both peripheral zone (PZ, P=0.01) and central gland (CG, P=0.01) of normal prostate tissue. The f value increased in the CG beginning at 50 years of age while the ADCuh value decreased in the PZ after 50 years of age; all of them showed significant differences between groups A and C and groups B and C (P=0.01/0.01). @@@ Conclusion: The D, ADCuh, and f values have good to excellent reproducibility in the normal prostate, and these values change with age. The ultrahigh b-values magnetic resonance imaging (MRI) can provide additional information (ADCuh), which is different from the IVIM (intravoxel incoherent motion)-derived parameters.

• 出版日期2017-9
• 单位广州市番禺区中心医院; 暨南大学