Assessment of Platelet Function on Whole Blood by Multiple Electrode Aggregometry in High-Risk Patients With Coronary Artery Disease Receiving Antiplatelet Therapy

作者：Paniccia Rita^*; Antonucci Emilia; Maggini Niccolo; Romano Eloisa; Gori Anna Maria; Marcucci Rossella; Prisco Domenico; Abbate Rosanna

来源：American Journal of Clinical Pathology, 2009, 131(6): 834-842.

DOI：10.1309/AJCPTE3K1SGAPOIZ

• Aspirin resistance
• Clopidogrel resistance
• Coronary syndrome
• Light transmission platelet aggregation
• Multiplate system
• Point-of-care testing
• Residual platelet reactivity
• Whole blood platelet aggregation

This study sought to compare Multiplate impedance platelet aggregometry (IPA) with light transmission aggregometry (LTA) and the PFA-100 for determining the prevalence of residual platelet reactivity (RPR) by the Multiplate IPA in 297 patients with acute coronary syndrome receiving dual antiplatelet therapy. Aggregations were induced by adenosine-5 diphosphate (ADP), arachidonic acid, and collagen, PFA-100 closure times were measured by collagen and ADP and epinephrine (CEPI) cartridges. Significant correlations were observed between Multiplate IPA and LTA after all stimulations (P < .0001) and between Multiplate IPA (arachidonate and collagen) and PFA-100 CEPI closure time (P < .0001 for both). Cutoff values of Multiplate IPA (for all stimulations) were calculated for the identification of RPR. Between the Multiplate IPA and LTA good agreement was found with all 3 agonists (P < .0001 for all). Multiplate IPA might represent a reliable, handy, rapid tool for monitor antiplatelet therapy in clinical practice and for clinical investigations.

• 出版日期2009-6