Delivery of endocytosed membrane proteins to the lysosome

作者：Pryor Paul R^*; Luzio J Paul

来源：Biochimica et Biophysica Acta-Molecular Cell Research, 2009, 1793(4): 615-624.

DOI：10.1016/j.bbamcr.2008.12.022

• Endocytosis
• Late endosomes
• Lysosomes
• Multivesicular body
• Membrane fusion

The delivery of proteins from the plasma membrane to the lysosome for degradation is essential for normal cellular function. There is now a good understanding of the protein complexes involved in sorting proteins at the plasma membrane and into the intralumenal vesicles of the multi-vesicular body. A combination of cell free content mixing assays and live-cell imaging has dissected out the final step in delivery of macromolecules to the lysosome from the multi-vesicular body and provided insights into the molecular mechanisms by which late endosomes and lysosomes exchange lumenal contents. The endocytic pathway has provided a platform with which to understand the autophagic and phagocytic pathways, but the fine details of how traffic through these pathways is regulated remain to be determined.

• 出版日期2009-4
• 单位河北医科大学