A new phragmalin-type limonoid and anti-inflammatory constituents from the fruits of Swietenia macrophylla

作者：Chen Jih Jung^*; Huang Sheng Shiou; Liao Chang Hui; Wei Dau Chang; Sung Ping Jyun; Wang Tai Chi; Cheng Ming Jen

来源：Food Chemistry, 2010, 120(2): 379-384.

DOI：10.1016/j.foodchem.2009.09.093

• Swietenia macrophylla
• Meliaceae
• Structure elucidation
• Phragmalin-type limonoid
• Anti-inflammatory activity

The fruit of Swietenia macrophylla is commercially used in healthcare products for the improvement of blood circulation and skin condition. A new phragmalin-type limonoid, 6-0-acety1-3'-demethylswietephragmin E (1), has been isolated from the fruit of S. macrophylla, together with 16 known compounds. The structure of this new compound was determined through spectroscopic and MS analyses. 6-O-Acetyl-3'-demethylswietephragmin E (1), 3,6-O,O-diacetylswietenolide (5), 3-O-tigloylswietenolide (6). 3-O-tigloyl-6-O-acetylswietenolide (8), swietemahonin E (9), and 6-O-acetylswietemahonin G (10) exhibited inhibition (IC(50) <= 35.7 mu M) Of Superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylaianine (fMLP).

• 出版日期2010-5-15
• 单位长春大学