A novel preparation of L-citrulline and L-homocitrulline

作者：Jia, Gen-Guang; Liu, Yi^*; Zheng, You-Guang; Zhang, Ling; Liu, Ling; Ling, Xin; Gou, Ling-Shan; Yin, Cui; Zhuang, Xue-Mei

来源：Journal of the Chemical Society of Pakistan, 2012, 34(2): 451-454.

• L-ornithine monohydrochloride
• L-citrulline monohydrochlori-de
• L-homocitrulline

L-citrulline was synthesized from L-ornithine monohydrochloride, which was treated with copper salt under alkaline conditions to protect alpha-NH2, followed by formylation of-delta-NH2 with carbamide, and the removal of copper ion via the combination with sulfides or organic acids to release L-citrulline in satisfactory yield. L-homocitrulline was prepared from L-lysine monohydrochloride with the same method. This new method has the advantages of being environmentally friendly and suitable for industrial production.

• 出版日期2012-4
• 单位徐州医科大学