科研之友
微信
新浪微博
Facebook
分享链接
摘要
2-Hydroxymethylpyridines undergo nickel-catalyzed hydrogenolysis upon activation with a chlorophosphate. Reactions employ diethylzinc and are proposed to proceed through secondary benzylzinc reagents. Quenching with deuteromethanol provides straightforward incorporation of a deuterium label in the benzylic position. Intramolecular conjugate additions with a, beta-unsaturated esters are also demonstrated and support the intermediacy of a benzylzinc complex.
- 出版日期2017-12-1
