Anti-melanin deposition activity of ceramicines from Chisocheton ceramicus

作者：Iijima Chie; Wong Chin Piow; Nugroho Alfarius Eko; Sotozono Yayoi; Someya Saki; Hirasawa Yusuke; Kaneda Toshio; Hadi A Hamid A; Morita Hiroshi^*

来源：Journal of Natural Medicines, 2016, 70(4): 702-707.

DOI：10.1007/s11418-016-1016-y

• Limonoids
• Ceramicines
• Chisocheton ceramicus
• Anti-melanin deposition
• Tyrosinase protein

The ceramicines, a series of limonoids from Chisocheton ceramicus (Meliaceae), were evaluated for anti-melanin deposition activity on alpha-melanocyte stimulating hormone (alpha-MSH) and 3-isobutyl-1-methylxanthine (IBMX)-treated B16-F10 melanoma cell, and several ceramicines were found to be active. The structure-activity relationship of ceramicines as anti-melanin deposition inhibitors was deduced. Furthermore, the mechanism of anti-melanin deposition activity of ceramicine B, a major constituent of C. ceramicus that showed potent anti-melanin deposition activity, was investigated. Tyrosinase enzymatic activity and tyrosinase mRNA expression were not affected by ceramicine B. The anti-melanin deposition activity of ceramicine B was shown to be related to the downregulation of tyrosinase protein expression. These results suggest that ceramicines have potential to be used as depigmentation agents.

• 出版日期2016-10