An analysis of the recurrence-progression process in bladder carcinoma by means of joint frailty models

作者：Santamaria C^*; Garcia Mora B; Rubio G; Lujan S

来源：Mathematical and Computer Modelling, 2011, 54(7-8): 1671-1675.

DOI：10.1016/j.mcm.2010.11.004

• Joint frailty model
• Survival analysis
• Event dependence
• Bladder carcinoma

Multiple sequential recurrences are one of the most important characteristics of superficial transitional cell carcinoma of the bladder, more than 50% of the patients will have recurrences (reappearance of a new superficial tumor). When in the same subject recurrent events are considered and these observed events are clustered into groups, independence between the clustered survival times cannot be assumed. A natural way to model the dependence of clustered event times is through the introduction of a cluster-specific random effect: the frailty term. On the other hand, between 10% and 30% of patients diagnosed with bladder carcinoma will present a muscle invasive progression, so the observation process of recurrences could be interrupted by a major failure event (progression). In this regard, a joint modelling of the two processes could make the study of a joint evolution over time possible, giving unbiased and efficient parameters. We jointly analyze recurrences and progression processes by means of the joint frailty model.

• 出版日期2011-10