A facile chemoselective deprotection of aryl silyl ethers using sodium hydride/DMF and in situ protection of phenol with various groups

作者：Fernandes Rodney A^*; Gholap Sachin P; Mulay Sandip V

来源：RSC Advances, 2014, 4(32): 16438-16443.

DOI：10.1039/c4ra00842a

An efficient method for the selective removal of aryl silyl protection using NaH in DMF solvent is developed. The method is rapid, operationally simple and can be carried out at room temperature. Excellent chemoselectivity and high yields of phenol products are other advantages of this method. A one-pot desilylation and reprotection as aryl alkyl ethers and esters has also been demonstrated.

• 出版日期2014