Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria

作者：Falkinham Joseph O III^*; Macri Richard V; Maisuria Bhadreshkumar B; Actis Marcelo L; Sugandhi Eko W; Williams Andre A; Snyder Alyson V; Jackson Faunice R; Poppe Michael A; Chen Liang; Ganesh Krithika; Gandour Richard D

来源：Tuberculosis, 2012, 92(2): 173-181.

DOI：10.1016/j.tube.2011.12.002

• Dendritic amphiphiles
• Nontuberculous mycobacteria
• Anti-mycobacterial agents
• Critical micelle concentration
• Hemolytic activity

The anti-mycobacterial activities of nine series of dicarboxyl and tricarboxyl dendritic amphiphiles with one alkyl, two alkyl, and cholestanyl tails against Mycobacterium abscessus, Mycobacterium avium, Mycobacterium chelonae, Mycobacterium marinum and Mycobacterium smegmatis have been measured. The dendritic amphiphiles overcame the limited aqueous solubility of natural long-chain fatty acids, alcohols, and amines to enable profiling the susceptibilities of the different mycobacterial species to the physicochemical properties of these amphiphiles. Several dendritic amphiphiles showed strong anti-mycobacterial activity with high critical micelle concentrations and low hemolytic activities thereby offering platforms for the development of antibiotics of higher activity against nontuberculous mycobacteria.

• 出版日期2012-3
• 单位Virginia Tech; 美国弗吉尼亚理工大学(Virginia Tech)