科研之友
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摘要
The cyclin-dependent kinase 9 (CDK9)-related pathway is a key factor in the regulation of mammalian cell biology. Its main role consists of regulating transcription via phosphorylation of the RNA polymerase II carboxyl-terminus domain (CTD), which in turn stabilizes the elongation of nascent RNA. CDK9 is also involved in the replication program of different types of viruses, such as HIV-7 and HIV-2, human T-lymphotropic virus type 7 (HTLV-1), Epstein-Barr virus, human cytomegalovirus and herpes simplex virus 7 (HSV-7). A deregulated CDK9-related pathway is also associated with various types of human cancers and cardiac hypertrophy. On these grounds, the CDK9-related pathway may be considered a suitable therapeutic target for the treatment of cancer, cardiac hypertrophy and the aforementioned viral diseases. This review describes the complex biology of the CDK9-related pathway and the status of drug development for the targeting of CDK9 and other CDKs in cancer therapy.
