Neuroprotective effects of cold-inducible RNA-binding protein during mild hypothermia on traumatic brain injury

作者：Wang, Guan^*; Zhang, Jian-ning; Guo, Jia-kui; Cai, Ying; Sun, Hong-sheng; Dong, Kun; Wu, Cheng-gang

来源：Neural Regeneration Research, 2016, 11(5): 771-778.

DOI：10.4103/1673-5374.182704

• nerve regeneration
• traumatic brain injury
• mild hypothermia
• cold-inducible RNA-binding protein
• mitogen-activated extracellular signal-regulated kinase
• anti-apoptosis
• neural regeneration

Cold-inducible RNA-binding protein (CIRP), a key regulatory protein, could be facilitated by mild hypothermia in the brain, heart and liver. This study observed the effects of mild hypothermia at 31 +/- 0.5 degrees C on traumatic brain injury in rats. Results demonstrated that mild hypothermia suppressed apoptosis in the cortex, hippocampus and hypothalamus, facilitated CIRP mRNA and protein expression in these regions, especially in the hypothalamus. The anti-apoptotic effect of mild hypothermia disappeared after CIRP silencing. There was no correlation between mitogen-activated extracellular signal-regulated kinase activation and CIRP silencing. CIRP silencing inhibited extracellular signal-regulated kinase-1/2 activation. These indicate that CIRP inhibits apoptosis by affecting extracellular signal-regulated kinase-1/2 activation, and exerts a neuroprotective effect during mild hypothermia for traumatic brain injury.

• 出版日期2016-5
• 单位天津中医药大学; 天津医科大学; 天津市环湖医院