Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model

作者：Muley Milind M; Thakare Vishnu N; Patil Rajesh R; Bafna Pallavi A; Naik Suresh R^*

来源：Life Sciences, 2013, 93(1): 51-57.

DOI：10.1016/j.lfs.2013.05.020

• Global ischemic rat model
• Cognitive and motor functions
• Oxidative stress
• PCA
• Piracetam
• Silymarin

Aims: The neuroprotective activities of silymarin, piracetam and protocatechuic acid ethyl ester (PCA) on cerebral global ischemic/reperfusion were evaluated in a rat model.
Main methods: A midline ventral incision was made in the throat region. The right and left common carotid arteries were located and a bilateral common carotid artery occlusion (BCCAO) was performed for 30 min using atraumatic clamps followed by a 24 h period of reperfusion. Neurological/behavioral functions (cognitive and motor), endogenous defense systems (lipid peroxidation, glutathione, catalase, and superoxide dismutase), reduced water content and infarct size and histopathological alterations were then studied.
Key findings: Silymarin and PCA treatments significantly improved cognitive, motor and endogenous defense functions, histopathological alterations, and, reduced both water content and infarct size compared to the vehicle-treated ischemic control group. Piracetam treatment improved neurological and histopathological alterations, reduced water content and infarct size, but failed to restore/prevent the impaired endogenous defense functions significantly.
Significance: Silymarin showed better neuroprotection than piracetam and PCA in experimentally induced global ischemic/reperfusion and was able to facilitate mnemonic performance.

• 出版日期2013-7-19