A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis

作者：Thulkar Jyoti^*; Kriplani Alka; Agarwal Nutan

来源：INDIAN JOURNAL OF PHARMACOLOGY, 2012, 44(2): 243-245.

DOI：10.4103/0253-7613.93859

• Bacterial vaginosis
• metronidazole
• ornidazole
• secnidazole
• tinidazole

Objective: To compare the cure rates of oral single dose of metronidazole (2 g), tinidazole (2 g), secnidazole (2 g), and ornidazole (1.5 g) in cases of bacterial vaginosis. Materials and Methods: This was a prospective, comparative, randomized clinical trial on 344 Indian women (86 women in each group) who attended a gynecology outpatient department with complaint of abnormal vaginal discharge or who had abnormal vaginal discharge on Gynecological examination but they did not complaint of it. For diagnosis and cure rate of bacterial vaginosis, Amsels criteria were used. Statistical analysis was done by Chi-square test of proportions. The cure rate was compared considering metronidazole cure rate as gold standard. Results: At 1 week, the cure rate of tinidazole and ornidazole was 100 and at 4 weeks, it was 97.7 for both drugs (P < 0.001). Secnidazole had cure rate of 80.2 at 4 weeks (P=NS). Metronidazole showed a cure rate of 77.9 at 4 weeks, which is the lowest of all four drugs. Conclusion: Tinidazole and ornidazole have better cure rate as compared to metronidazole in cases of bacterial vaginosis.

• 出版日期2012-4
• 单位河北医科大学