ULBP1 is induced by hepatitis C virus infection and is the target of the NK cell-mediated innate immune response in human hepatocytes

作者：Dansako Hiromichi^*; Imai Hirotaka; Ueda Youki; Satoh Shinya; Wakita Takaji; Kato Nobuyuki

来源：FEBS Open Bio, 2018, 8(3): 361-371.

DOI：10.1002/2211-5463.12373

• HCV RNA replication
• hepatitis C virus
• innate immune response
• NK cell
• ULBP1

Natural killer (NK) cells through their NK group 2 member D (NKG2D) receptors recognize NKG2D ligands such as UL16-binding proteins (ULBPs) on virus-infected cells and subsequently trigger the host innate immune response. In the present study, we demonstrated that hepatitis C virus (HCV) induced the cell surface expression of ULBP1 in human immortalized hepatocyte PH5CH8 cells and human hepatoma HuH-7 cell-derived RSc cells. Interestingly, NK cell line NK-92 induced cytotoxicity and interferon- mRNA expression and subsequently reduced the levels of HCV RNA replication during co-culture with HCV-infected RSccells. From these results, we conclude that ULBP1 is a target of the NK cell-mediated innate immune response in HCV-infected human hepatocytes.

• 出版日期2018-3