New Strategy for Overcoming Resistance to Chemotherapy of Ovarian Cancer

作者：Kigawa Junzo^*

来源：Yonago Acta Medica, 2013, 56(2): 43-50.

• chemotherapy
• molecular targeted agent
• ovarian cancer
• resistance

Background Ovarian cancer is one of the most sensitive solid tumors, with objective responses ranging from 60 to 80% even in patients with advanced stage. However, most patients ultimately recur and develop resistance to chemotherapy. As a result, the survival rate for patients with ovarian cancer has not improved over the past 20 years. Resistance to chemotherapy presents a major obstacle to attempt to improve the prognosis of patients with ovarian cancer. A new strategy is necessary to improve the prognosis of patients with ovarian cancer. %26lt;br%26gt;Methods The mechanism of chemoresistance was reviewed to get over the resistance. Additionally, the biological characteristics of ovarian cancer and molecular-targeted agents including signal-transduction inhibitors and anti-angiogenesis were discussed. %26lt;br%26gt;Results Genetic diagnosis for chemosensitivity with drug-resistance genes may be a useful predictor. Unfortunately, molecular-targeted therapy alone has been insufficient to improve the prognosis for patients with advanced ovarian cancer. Molecular molecular-targeted therapy should be carried out together with conventional cytotoxic agents. On the occasion of the use of the molecular targeted-agents, care of the appearance of the unexpected adverse effect should be important. %26lt;br%26gt;Conclusion The future research in this field will enable to develop an effective strategy for conquest of chemoresistance in ovarian cancer.

• 出版日期2013-6