ERK 1/2 Activation Mediates the Neuroprotective Effect of BpV(pic) in Focal Cerebral Ischemia-Reperfusion Injury

作者：Liu, Rui; Tang, Jun-Chun; Pan, Meng-Xian; Zhuang, Yang; Zhang, Ya; Liao, Hua-Bao; Zhao, Dan; Lei, Yang; Lei, Rui-Xue; Wang, Shu; Liu, An-Chun; Qin, Xing-Ping; Chen, Juan; Zhang, Zhi-Feng^*; Wan, Qi^*

来源：Neurochemical Research, 2018, 43(7): 1424-1438.

DOI：10.1007/s11064-018-2558-z

• PTEN
• BpV(pic)
• Cerebral ischemia
• AKT
• ERK 1/2

Bisperoxovanadium (pyridine-2-carboxyl) [bpV(pic)] is a commercially available PTEN inhibitor. Previous studies from us and others have shown that bpV(pic) confers neuroprotection in cerebral ischemia injury. We set up to determine whether ERK 1/2 activation plays a role in bpV(pic)-induced neuroprotective effect in cerebral ischemia injury. We found that the phosphorylation levels of Akt (p-AKT) and ERK1/2 (p-ERK 1/2) were down-regulated after cerebral ischemia-reperfusion injury. The injection of bpV(pic) after injury not only increased the level of p-AKT but also the level of p-ERK 1/2. While the inhibition of PTEN mediated the up-regulatation of p-AKT and p-ERK 1/2 by bpV(pic). Interestingly, the ERK 1/2 activation induced by bpV(pic) was also independent of the inhibition of PTEN. Our results indicate that bpV(pic) protects against OGD-induced neuronal death and promotes the functional recovery of stroke animals through PTEN inhibition and ERK 1/2 activation, respectively. This study suggests that the effect of bpV(pic) on ERK 1/2 signaling should be considered while using bpV(pic) as a PTEN inhibitor.

• 出版日期2018-7
• 单位华中科技大学; 青岛大学; 武汉大学; 湖北医药学院; 武汉市中心医院