Allgrove syndrome: a report of a unique case characterised by peculiar dental findings resembling those of ectodermal dysplasia

作者：Tadini G^*; Besagni F; Callea M; Brena M; Rossi L C; Angiero F; Crippa R

来源：European Journal of Paediatric Dentistry, 2015, 16(4): 324-326.

• Allgrove Syndrome
• AAAS gene
• Conical shaped teeth
• Ectodermal Dysplasia
• Enamel hypoplasia
• Hypodontia

Background Triple A or Allgrove Syndrome (OMIM#231550) is a rare, autosomal recessive genetic disorder in which patients typically suffer from chronic adrenal insufficiency due to resistance to ACTH (Addison's disease), esophageal achalasia, and defective tear formation (alacrima). The syndrome is caused by mutations in the AAAS gene on chromosome 12q13 encoding a 546 aminoacid protein named alacrimia-achalasia-adrenal insufficiency neurologic disorder (ALADIN), a constituent of eukaryotic nuclear pore complexes.
Case report We describe a case of Allgrove Syndrome presenting with anhidrosis and peculiar dental features resembling those of Ectodermal Dysplasia (ED).
Conclusion Given the clinical findings in this case we suggest the hypothesis that the pathogenetic mechanism in Allgrove syndrome is related to the ED.

• 出版日期2015