Anticancer activity of chemically prepared shrimp low molecular weight chitin evaluation with the human monocyte leukaemia cell line, THP-1

作者：Salah R; Michaud P; Mati F; Harrat Z; Lounici H; Abdi N; Drouiche N^*; Mameri N

来源：International Journal of Biological Macromolecules, 2013, 52: 333-339.

DOI：10.1016/j.ijbiomac.2012.10.009

• Anticancer
• Chitin
• Chitosan
• THP-1
• MRC-5

In the present study, anticancer activities of chitin, chitosan and low molecular weight chitin were evaluated using a human tumour cell line, THP-1. A molecular weight-activity relationship and an electrostatic interaction-activity relationship were determined. The cytotoxic effects of chitin and derivatives were also evaluated using a normal human foetal lung fibroblastic cell line, MRC-5 and the specific cytotoxicity of chitin and derivatives to tumour cell lines was demonstrated. The high antitumour effect of low molecular weight of chitin was established.

• 出版日期2013-1