Disentangling Complex Mixtures of Compounds with Near-Identical H-1 and C-13 NMR Spectra using Pure Shift NMR Spectroscopy

作者：Castanar Laura; Roldan Raquel; Clapes Pere; Virgili Albert; Parella Teodor^*

来源：Chemistry - A European Journal, 2015, 21(21): 7682-7685.

DOI：10.1002/chem.201500521

• homodecoupling
• mixture analysis
• NMR spectroscopy
• pure shift NMR
• spectral aliasing

The thorough analysis of highly complex NMR spectra using pure shift NMR experiments is described. The enhanced spectral resolution obtained from modern 2D HOBS experiments incorporating spectral aliasing in the C-13 indirect dimension enables the distinction of similar compounds exhibiting near-identical H-1 and (CNMR)-C-13 spectra. It is shown that a complete set of extremely small (H-1) and (C-13) values, even below the natural line width (1 and 5 ppb, respectively), can be simultaneously determined and assigned.

• 出版日期2015-5-18