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摘要
Based on the oxidation of 1,5-naphthalenediol (4) and 6-bromo-2-naphthol (9) via Teuber reaction, an efficient synthesis of 5,6-dimethoxy-1-naphthol (1) and 5,6-dimethoxy-2-naphthol (2) was achieved with high overall yield (16% for 1 and 25% for 2). The key steps of the synthetic strategy involved the oxidation of naphthols (4 and 9) to the corresponding naphthoquinones (5 and 10) and the conversion of 5,6-dimethoxy-2-naphthaldehyde to 5,6-dimethoxy-2-naphthol formate through Baeyer-Villiger oxidation-rearrangement.
- 出版日期2013-9
- 单位上海交通大学
