The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern

作者：Lin Wei Ting David; Huang Po Jung Jimmy; Pautler Rachel; Liu Juewen^*

来源：Chemical Communications, 2014, 50(80): 11859-11862.

DOI：10.1039/c4cc05551a

Using sensitized Tb3+ luminescence spectroscopy as a tool, binding of 14 lanthanides to a lanthanide-dependent DNAzyme is studied, where the binding affinity is symmetric across the series and the tightest binding occurs with Nd3+ and Ho3+. This trend does not correlate with DNAzyme activity, suggesting that metal binding may not be the rate-limiting step of the DNAzyme catalysis.

• 出版日期2014