Diastereoselective Synthesis of Functionalized Diketopiperazines through Post-transformational Reactions

作者:Balalaie Saeed*; Kejani Reihaneh Ramezani; Ghabraie Elmira; Darvish Fatemeh; Rominger Frank; Hamdan Fatima; Bijanzadeh Hamid Reza
来源:Journal of Organic Chemistry, 2017, 82(23): 12141-12152.
DOI:10.1021/acs.joc.7b01855

摘要

A diversity-oriented access to diastereoselective arylidene 2,5-diketopiperazines is elaborated via a sequential Ugi post-transformation involving catalytic cyclization and oxidative Heck reaction sequence. This sequence offers an interesting multicomponent entry to a library of 2,5-diketopiperazines and arylidene 2,5-diketopiperazines under mild reaction conditions in good to excellent yields.

  • 出版日期2017-12-1