Using inflammatory and oxidative biomarkers in urine to predict early acute kidney injury in patients undergoing liver transplantation

作者：Liu, Dezhao; Huang, Pinjie; Li, Xiaoyun; Ge, Mian; Luo, Gangjian; Hei, Ziqing^*

来源：Biomarkers, 2014, 19(5): 424-429.

DOI：10.3109/1354750X.2014.924997

• Acute kidney injury (AKI)
• inflammation orthotopic liver transplantation (OLT)
• oxidative stress
• urinary biomarkers

Objective: We examined the value of inflammatory and oxidative biomarkers in predicting acute kidney injury (AKI) following orthotopic liver transplantation (OLT).
Methods: Urinary excretion of tumour necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), interleukin-10 (IL-10), superoxide dismutase (SOD), malondialdehyde (MDA), 6-keto prostaglandin F-1 alpha (6-keto-PGF(1 alpha)), hydrogen peroxide (H2O2), and 8-keto prostaglandin F-2 alpha (8-iso-PGF(2 alpha)), serum creatinine (SCr), blood urea nitrogen (BUN), urinary N-acetyl-beta-D-glucosaminidase (NAG), beta(2)-microglobulin (beta(2)-MG) and gamma-glutamyl-transferase (gamma-GT), were measured before surgery (baseline), at 2 h after graft reperfusion and 24 h after OLT in 28 liver transplantation patients.
Results: The levels of TNF-alpha, IL-8, IL-10, SOD, MDA, 6-keto-PGF(1 alpha), H2O2 and 8-iso-PGF(2 alpha) in urine were all significantly higher in patients who had AKI than in those who did not at 2 h after graft reperfusion and 24 h after OLT (p<0.01).

• 出版日期2014-8
• 单位中山大学