Anti-cyclic citrullinated peptide antibodies are not associated with familial Mediterranean fever

作者：Karatay Saliha^*; Yildirim Kadir; Erdal Akin; Uzkeser Hulya; Erdem Fazile Hatipoglu; Yanmaz Vefa

来源：Journal of Back and Musculoskeletal Rehabilitation, 2010, 23(1): 21-23.

DOI：10.3233/BMR-2010-0243

• Familial Mediterranean fever
• arthritis
• anti-cyclic citrullinated peptide antibodies

Objective: This study investigated the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in familial Mediterranean fever (FMF) patients and controls.
Material and Methods: Forty-nine patients with FMF were enrolled (23 had a history of arthritis during attacks and 26 had no such history). Two control groups were enrolled: 20 patients with rheumatoid arthritis (RA) and 30 healthy individuals. Clinical and laboratory assessments of the FMF patients were performed during attack-free periods. Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), rheumatoid factor (RF), and anti-CCP antibody levels were measured.
Results: In RA patients' ESR and CRP levels, frequency of RF, and anti-CCP antibody levels were significantly higher than in both FMF patients and healthy controls (p <= 0.001). Moreover, anti-CCP was negative in all healthy controls as well as in all FMF patients.
Conclusion: Our results show that anti-CCP antibodies are not associated with FMF.

• 出版日期2010