Double- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade

作者：Meletis G^*; Chatzidimitriou D; Malisiovas N

来源：European Journal of Clinical Microbiology & Infectious Diseases, 2015, 34(8): 1487-1493.

DOI：10.1007/s10096-015-2379-9

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative nosocomial pathogens commonly carry one carbapenemase gene conferring resistance to carbapenems and other beta-lactam antibiotics. However, increasing reports show that double-carbapenemase-producing (DCP) and even multi-carbapenemase-producing (MCP) bacteria are emerging in some parts of the world, diminishing further, in some cases, the already limited treatment options. In the present review, the up-to-date reports of DCP and MCP isolates are summarized and concerns regarding their emergence are discussed.

• 出版日期2015-8