Stable Isotope Dilution Assay of Bisphenol A, Bisphenol F and Bisphenol S from Thermal Paper Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry

作者：Zech Julie^*; Manowski Aneta; Schulze Anne Kathrin; Canitz Carsten; Neumann Konrad; Garbe Leif Alexander

来源：Deutsche Lebensmittel-Rundschau, 2015, 111(3): 129-136.

A stable isotope dilution assay (SIDA) was developed to quantify bisphenol A (BPA), bisphenol F (BPF), and bisphenol S (BPS) from thermal paper by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The SIDA was verified for BPA, BPF, and BPS resulting in average recoveries from 106 to 115 A. d(4)-lsotope standards were applied to determine bisphenols contained on supermarket receipts (n = 14) from Berlin, Germany. BPA values of 0.07 to 20.1 mg/g paper weight were determined. One receipt contained 6.43 mg/g BPS; BPF was not detected. Synthesis of 2,6-dideuterio-4-[1-(3,5-dideuterio4-hydroxy-phenyl)-1-methyl-ethyl]phenol (BPA-d(4)), 2,6-dideuterio-4[(3,5-dideuterio-4-hydroxy-phenyl)methyl]phenol (BPF-d(4)), and 2,6-dideuterio-4-(3,5-dideuterio-4-hydroxy-phenyl)sulfonyl-phenol (BPS-d(4)) is described. BPA and BPF were labeled directly via acid induced hydrogen-deuterium exchange reaction in deuterium oxide, while BPS was deuterated by labeling 4-(4-hydroxyphenyl)sulfanylphenol followed by oxidation of the intermediate.

• 出版日期2015-3