Hybrid biodegradable membranes of silane-treated chitosan/soy protein for biomedical applications

作者：Silva Simone S^*; Oliveira Joaquim M; Benesch Johan; Caridade Sofia G; Mano Joao F; Reis Rui R

来源：Journal of Bioactive and Compatible Polymers, 2013, 28(4): 385-397.

DOI：10.1177/0883911513490361

• Soy protein
• hybrid materials
• chitosan
• biomaterials
• tetraethoxysilane

In recent years, progress in the field of hybrid materials has been accelerated through use of the sol-gel process for creating materials and devices, which benefit from the incorporation of both inorganic and organic components. In this work, organic-inorganic hybrid membranes were prepared from tetraethoxysilane and a blend system composed of chitosan and soy protein. By introducing a small amount of siloxane bond into the chitosan/soy protein system, the chitosan/soy protein hybrid membranes were improved in terms of structure, topography and mechanical properties. It appears that the chitosan/soy protein hybrid membranes were formed by discrete inorganic moieties entrapped in the chitosan/soy protein blend, which improved the stability and mechanical performance assessed by the dynamic mechanical analysis as compared to chitosan/soy protein membrane. Also, in vitro cell culture studies evidenced that the chitosan/soy protein hybrid membranes are non-cytotoxic over a mouse fibroblast-like cell line. The hybrid membranes of silane-treated chitosan/soy protein developed in this work have potential in biomedical applications, including tissue engineering.

• 出版日期2013-7