科研之友
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摘要
Objective: To explore the hearing outcomes and prognostic factors in patients with sudden sensorineural hearing loss resulting from inner ear hemorrhage. @@@ Methods: 42 patients (22 male and 20 female) were recruited from January 2016 to December 2017. Intravenous methylprednisolone and/or intratympanic corticosteroid were used as salvage therapy. The main measures included systemic risk factors and audiometric outcomes as proposed by American Academy of Otolaryngology Head and Neck Surgery Hearing Loss Scale. All individuals were assessed at baseline, discharge (2 weeks posttreatment) and at 1, 3 and 6 months. @@@ Results: The mean ages of patients were 39.3 +/- 14.8 yrs. Cardiovascular disorders were seen in 19.0-33.3% of cases. Restoration of hearing and speech discrimination abilities were assessed at the first month post-treatment versus initial levels (95.5 +/- 15.5 vs. 109.2 +/- 9.6 dB, p = 0.000; and 17.6 +/- 24.4 vs. 1.3 +/- 4.0%, p = 0.003, respectively). Word recognition scores continued to recover at month 6 (38.7 +/- 35.4%, p = 0.000), whereas puretone ceased to change (90.8 +/- 16.2 dB, p = 0.139). The final percentages of complete, partial and no recovery were 0%, 57.1% and 42.9% respectively. The prognosis was independent of accompanying systemic risk factors as analyzed in this study. Intratympanic intervention was associated with improved word recognition scores, although intravenous corticosteroid was not. @@@ Conclusions: Profound sudden sensorineural hearing loss caused by inner ear hemorrhage often has an unsatisfactory prognosis. However, this cohort did experience partial audiological recovery with delayed onset. Immediate and effective intratympanic corticosteroid may have therapeutic potential for this intractable disease.
