DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

作者：Lee Byeong Taek; Lee Hwa Young; Han Changsu; Pae Chi Un; Tae Woo Suk; Lee Min Soo; Joe Sook Haeng; Jung In Kwa; Ham Byung Joo^*

来源：Behavioural Brain Research, 2011, 223(1): 36-41.

DOI：10.1016/j.bbr.2011.04.007

• Dopamine receptor D2
• Polymorphism
• fMRI
• Striatum

DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

• 出版日期2011-9-30