科研之友
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摘要
Background: MicroRNA-433 (miR-433), possessing tumor suppressive activity, has been found to be down-regulated in different types of cancer. However, its clinical significance in epithelial ovarian cancer (EOC) is still unclear. Therefore, the aim of this study was to detect the miR-433 expression and its prognostic value in patients suffering from EOC. Methods: The miR-433 expression was detected by quantitative real-time polymerase chain reaction (qRT-PCR) analysis in 115 EOC tissues and 45 normal tissues. Then, the associations of miR-433 expression with clinicopathologic characteristics as well as overall survival of EOC patients were determined by Chi-square test and Kaplan-Meier method respectively. Besides, the prognostic value of miR-433 was estimated via Cox regression analysis. Results: The expression of miR-433 in EOC tissues were significantly lower than that in normal tissues (P<0.05). In addition, low miR-433 expression was found to be closely correlated with tumor size (P=0.050), advanced FIGO stage (P=0.009), and recurrence (P=0.002). Moreover, the Kaplan-Meier analysis demonstrated that EOC patients with low miR-433 expression had a poorer overall survival than those with high miR-433 expression (P=0.000). Furthermore, the multivariate analysis identified miR-433 (P=0.013; HR=2.973; 95% CI=1.260-7.012) was an independent prognostic factor for EOC patients. Conclusion: For the first time, the current study offered convincing evidence that the expression of miR-433 was decreased in EOC and it might be associated with tumor progression of EOC. Therefore, miR-433 may be an independent prognostic marker for EOC patients.
- 出版日期2016
- 单位潍坊市人民医院
