ESBL genes in Multi Drug Resistant Gram negative strains isolated in a one year survey from an Intensive Care Unit in Bucharest, Romania

作者：Czobor Ilda; Gheorghe Irina^*; Banu Otilia; Velican Alexandra; Lazar Veronica; Mihaescu Grigore; Chifiriuc Mariana Carmen

来源：Romanian Biotechnological Letters, 2014, 19(4): 9553-9560.

• beta-lactams
• ESBL producers
• Pseudomonas aeruginosa
• Acinetobacter baumannii
• Enterobacteriaceae

The present study was designed to evaluate the antimicrobial susceptibility patterns of Multi Drug Resistance (MDR) and to determine the genes encoding Extended Spectrum beta-Lactamases (ESBLs) in clinical isolates of Enterobacteriaceae and non-fermenting Gram negative rods (NFGNR) (Pseudomonas aeruginosa and Acinetobacter baumannii) circulating in an intensive care unit of a Cardiovascular Diseases Prof. C.C. Iliescu from Bucharest (CCI), Romania, isolated during 2012-2013. %26lt;br%26gt;The most prevalent ESBLs in Enterobacteriaceae isolates were bla(CTX-M), bla(TEM) and bla(SHV), while in NFGNR were bla(GES), bla(SHV) and bla(VEB) genes. This study is the first report of VEB-like enzymes in Romania. %26lt;br%26gt;The presence of ESBLs in MDR strains has important implications as carbapenems remain the only choice of treatment for infections caused by these organisms. The control measures include judicious use of antibiotics and implementation of appropriate infection control measures to control the spread of these strains in the hospital environment.

• 出版日期2014-8