Association between accumulation of visceral fat and the combination of beta 3 adrenergic receptor Trp64Arg, beta 2 adrenergic receptor Arg16Gly and uncoupling protein 1-3826A > G polymorphisms detected by Smart Amplification Process 2

作者：Tsunekawa Katsuhiko^*; Yanagawa Yoshimaro; Aoki Tomoyuki; Morimura Tadashi; Araki Osamu; Ogiwara Takayuki; Kawai Yuki; Mitani Yasumasa; Lezhava Alexander; Yanagawa Masumi; Hayashizaki Yoshihide; Murakami Masami

来源：Endocrine Journal, 2011, 58(12): 1079-1086.

DOI：10.1507/endocrj.EJ11-0148

• Visceral fat
• Smart Amplification Process (SmartAmp)
• beta 2 adrenergic receptor
• beta 3 adrenergic receptor
• Uncoupling protein 1

beta 2 and beta 3 adrenergic receptors (beta 2AR, beta 3AR) and uncoupling protein 1 (UCP1) have been considered as candidate genes for obesity. Although each polymorphism of beta 3AR Trp64Arg, beta 2AR Arg16Gly and UCP1 -3826A>G is known to be associated with obesity, the interaction among these polymorphisms is not fully understood. We analyzed beta 3AR Trp64Arg, beta 2AR Arg16Gly and UCP1 -3826A>G polymorphisms by the Smart Amplification Process 2 in 222 Japanese subjects without the medication of hypertension, dyslipidemia or diabetes, and investigated the association between the physical and metabolic characteristics and the combination of these polymorphisms. In analysis of the genotypes combination, only the carriers of both beta 2AR Arg/Arg and UCP1 G/G genotypes had significantly higher waist to hip ratio (p=0.014). In analysis of the alleles combination, a significant difference was observed in waist to hip ratio among the groups stratified by the carrying number of the alleles of beta 3AR Arg, beta 2AR Arg and UCP1 G (p=0.026), and the waist to hip ratio was significantly higher in the carriers of four and five risk alleles than in the carriers from zero to three risk alleles (p=0.005). The present study demonstrated the interaction among beta 3AR Trp64Arg, beta 2AR Arg16Gly and UCP1 -3826A>G for the accumulation of visceral fat.

• 出版日期2011-12