科研之友
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摘要
A series of alpha-aminophosphonates were synthesized through one-pot condensation of aryl aldehydes, aryl amines and diethyl phosphite in the absence of any catalyst and organic solvents. All the synthesized alpha-aminophosphonates were characterized by spectral and elemental analysis and in the case of compound 4j by X-ray crystallography. Some of these new alpha-aminophosphonate derivatives were found to have cytotoxic activity on the cancer cell line DU145 in vitro by the MTT method.
- 出版日期2015-12
