Antifungal activity of 9-hydroxy-folianin and sucrose octaacetate from the seeds of Annona cornifolia A. St. -Hil. (Annonaceae)

作者：Lima Luciana A R S^*; Johann Susana; Cisalpino Patricia S; Pimenta Lucia P S; Boaventura Maria Amelia D

来源：Food Research International, 2011, 44(7): 2283-2288.

DOI：10.1016/j.foodres.2010.11.030

• Antifungal activity
• Annona cornifolia
• 9-Hydroxy-folianin
• Sucrose octaacetate
• Paracoccidioides brasiliensis

In this study, 9-hydroxy-folianin and sucrose octaacetate were isolated from the seed ethanol extract of Annona comifolia A. St. -Hil. (An nonaceae). We found that 9-hyd roxy-fol ianin was able to inhibit several clinical strains of the pathogenic fungus Paracoccidioides brasiliensis. The minimal inhibitory concentrations of 9-hydroxy-folianin against twelve clinical strains of P. brasiliensis were found to be in the range between 3.4 and 27.714 mu g mL(-1) and were much more potent than the commercial antifungal trimethropin-sulfamethoxazole. P. brasiliensis isolates (Pb-18, Pb-11, Pb-01, Pb-B339, Pb-8 and Pb-18 virulent) were also susceptible to sucrose octaacetate. The growth of Candida albicans, C tropicalis, C. parapsilosis and Cryptococcus gattii were not affected by these compounds. Sucrose octaacetate and 9-hydroxy-folianin showed no effects with amphotericin B and trimethropin-sulfamethoxazole, but they displayed a synergetic effect with itraconazole.

• 出版日期2011-8