An Integral Approach to Master Physicochemical Properties in the Solid Chain of a Colloidal Pharmaceutical Product

作者：Feist M^*; Akguen E; Nirschl H; Bieri N; Schreiner A

来源：Separation Science and Technology, 2011, 46(1): 46-53.

DOI：10.1080/01496395.2010.484408

• colloids
• microparticles
• precipitation
• sedimentation
• washing

In a wide range of industrial applications particle design is governed by the process precipitation followed by isolation like filtration or washing and drying. Particle characteristics play a crucial role on the behavior of the suspension during all production steps. This especially counts for pigments or dye stuff as well as for life science products. Particularly in the pharmaceutical industry bioavailability of a product is of utmost importance, which is often improved by designing colloidal particle collectives with a high surface area, however, often compromising the solid-liquid separation efficiency. This study is concerned with the interaction between crystallization, sedimentation, and washing efficiency all impacted by physical chemical properties of the particles itself, but also on the liquid phases used. The effect of dosage time of the reactants, stirrer speed, ionic strength, and pH-value are investigated in the precipitation process and on their impact on the solid-liquid separation behavior.

• 出版日期2011