Analysis of Amaryllidaceae Alkaloids from Chlidanthus fragrans by GC-MS and their Cholinesterase Activity

作者：Cahlikova Lucie^*; Macakova Katerina; Zavadil Stanislav; Jiros Pavel; Opletal Lubomir; Urbanova Klara; Jahodar Ludek

来源：Natural Product Communications, 2011, 6(5): 603-606.

• Chlidanthus fragrans
• Amaryllidaceae
• GC/MS
• acetylcholinesterase
• butyrylcholinesterase

The underivatized alkaloid mixture extracted from the bulbs of Chlidanthus fragrans Herb. was investigated by capillary GC/MS for the first time. Fifteen known Amaryllidaceae alkaloids of five structure types were identified. The main alkaloids were tazzetine (9, tazettine-type), chlidanthine (2, galanthamine-type), belladine (8, belladine-type) and lycorine (12, lycorine-type). The alkaloid extract from the bulbs showed promising human blood acetylcholinesterase (IC(50) = 20.1 +/- 2.9 mu g/mL) and human plasma butyrylcholinesterase (IC(50) = 136.8 +/- 6.9 mu g/mL) inhibitory activity.

• 出版日期2011-5